ub8优游注册

以后地位:  ub8优游注册 >> 最新主要论文

最新主要论文

NyuWa Genome resource: A deep whole-genome sequencing-based variation profile and reference panel for the Chinese population, Cell Rep, 16 Nov 2021

宣布时候:2021年11月16日

Cell Reports, 16 November, 2021, DOI:

NyuWa Genome resource: A deep whole-genome sequencing-based variation profile and reference panel for the Chinese population

Peng Zhang, Huaxia Luo, Yanyan Li, You Wang, Jiajia Wang, Yu Zheng, Yiwei Niu, Yirong Shi, Honghong Zhou, Tingrui Song, Quan Kang, Tao Xu, Shunmin He  

Abstract

The lack of haplotype reference panels and whole-genome sequencing resources specific to the Chinese population has greatly hindered genetic studies in the world’s largest population. Here, we present the NyuWa genome resource, based on deep (26.2×) sequencing of 2,999 Chinese individuals, and construct a NyuWa reference panel of 5,804 haplotypes and 19.3 million variants, which is a high-quality publicly available Chinese population-specific reference panel with thousands of samples. Compared with other panels, the NyuWa reference panel reduces the Han Chinese imputation error rate by a margin ranging from 30% to 51%. Population structure and imputation simulation tests support the applicability of one integrated reference panel for northern and southern Chinese. In addition, a total of 22,504 loss-of-function variants in coding and noncoding genes are identified, including 11,493 novel variants. These results highlight the value of the NyuWa genome resource in facilitating genetic research in Chinese and Asian populations.

文章链接:

相干报道:http://www.tattoosoption.com/kyjz/zxdt/202111/t20211115_6255882.html

 

 

    附件下载: